Adherence and diet type
Three randomized trials put popular or contrasting diets side by side and measured who kept following them. In the first, 160 adults were assigned to Atkins, Zone, Weight Watchers, or Ornish, and mean weight loss at one year ran from 2.1 kg to 3.3 kg across the four groups (Dansinger et al., JAMA, January 2005). Amount of weight loss was associated with self-reported dietary adherence level (r = 0.60) and was not associated with diet type (r = 0.07), and only 50% to 65% of each group completed the year (Dansinger 2005). The authors' conclusion names the real problem: overall dietary adherence rates were low, although increased adherence was associated with greater weight loss for each diet group.
The second trial assigned 811 adults to four diets with different shares of fat, protein, and carbohydrate (Sacks et al., NEJM, February 2009). At 6 months every group had lost an average of 6 kg, about 7% of initial weight, and they began to regain after 12 months. By two years weight loss was similar across all four diets, and attendance at group sessions was strongly associated with weight loss, at 0.2 kg per session attended (Sacks 2009). The conclusion was that reduced-calorie diets result in clinically meaningful weight loss regardless of which macronutrients they emphasize.
The third put 609 adults on a healthy low-fat or a healthy low-carbohydrate diet for 12 months (Gardner et al., DIETFITS, JAMA, February 2018). Weight change was -5.3 kg on low-fat and -6.0 kg on low-carbohydrate, a difference of 0.7 kg that was not significant, and neither genotype pattern nor baseline insulin secretion predicted which diet worked better for whom (DIETFITS 2018).
The obesity guideline from the American Heart Association, the American College of Cardiology, and The Obesity Society reads the same literature and says a variety of dietary approaches can produce weight loss in overweight and obese adults (AHA/ACC/TOS, Circulation, November 2013).


